由于一同车祸，高智商低情商的学霸女查小刀（孙俪 饰）不测相遇专职替人讨债的恶棍莫非里（邓超 饰）。被莫非里狠狠敲诈一笔的查小刀意志消沉，回想自己与母亲隔绝关系，任务被老板开除便愈加绝望。偶然间查小刀看到专治心思疑问杂症折耳根神医（梁超 饰）的广告，走投无路的她决议去神医处求救，没想到在诊所再次遭遇恶棍莫非里。惊慌失措的查小刀惧怕见到恶棍莫非里，却没想到被急于转移视野的神医当做“药”引见给了患有严重失眠症的莫非里。神医也通知查小刀，莫非里也是能治好她心思效果的“药”，消除疑虑的查小刀摩拳擦掌。而也因此，性情悬殊的二人成为拍档。两人一个极端嚣张跋扈，一个极端懦弱害怕，在讨债的进程里发作了一连串紧张抚慰又亦笑亦泪的故事。 Because of a car accident, a high IQ low EQ Curve Wrecker female check knife (Sun Lishi) who encounter villains in full-time Dun Murphy (Deng Chaoshi). It is hard in blackmail check knife depressed, think about your relationship with her mother to work was fired by the boss will become more desperate. Accidentally check knife see psychological doctor cures Difficult miscellaneous diseases zhe Ergen (Liang Chao) advertising, she decided to help the doctor cornered, unexpectedly in the clinic encounters the villain in it. Confound check for fear of seeing the villain is a knife, but did not expect to be eager to divert the doctor as "medicine" was introduced to suffering from severe insomnia is. Check the doctor told the knife, Murphy is able to cure her psychological problems in "medicine", the knife to reassure check. Thus, two different personalities become partner. Two an extremely arrogant and despotic, an extreme cowardice, there has been a series of exciting and laugh and tears the story in the process of collection.